Best Nootropic Supplements (2023) Top Brain Booster Smart Drug Pills for Men & Women

Best Nootropic Header

Whether you are a student willing to excel in your examination or a busy professional hoping for a raise, you must have thought to improve your mental energy in one way or the other.

This thought may have also led you to take a prescription drug to boost your mental performance. Well, in that case, you might be familiar with nootropic supplements, also remarked as smart drugs that are pretty popular for their stimulating effects on your cognitive performance.

Here in this write-up, we have curated a list of the Best Nootropic Supplements that are carefully selected and listed based on their efficacy, rapid results, and side-effect-free nature.

All the nootropic supplements discussed below are formulated with potent ingredients to support brain health effectively. So, without further ado, let us directly jump to the checklist:

Oweli Neuro One of the top supplements to boost brain health.
Nuzena Neuro Focus+ It helps you achieve laser-like focus
Nootrogen It improves mental health and elevates mood.
Onnit Alpha Brain It comes from a reputed company called Onnit which formulates leading-edge supplements.
Qualia Mind Works for all individuals irrespective of gender.
Vital Plan Brain Boost Prevents mental fatigue and stress burnout.
Synapse XT Comes from one of the best and leading companies in the supplement industry.
NeuroFuel It fuels your brain to help you achieve maximum mental performance.
Mind Lab Pro It elevates energy and mood while boosting brain health.
NooBru Supports improvement in concentration, memory retention, imagination, etc.
Ageless Brain It promotes optimized learning and is suitable for a wide range of users.
Hunter Focus Hunter Focus is one of the best nootropics developed by specialist supplement producer Roar Ambition.
Mind Performance Lab Mind can help you recover from intense cognitive exertion.
NeuroActive6 The formulation of these best nootropics dietary supplements is non-GMO, gluten-free, keto-friendly, dairy-free, and soy-free.
NooCube The powerful formulation of this natural nootropics supplement is caffeine-free and prescription drug-free.

The Best Nootropic Supplements for 2023

Nootropics, also known as smart drugs, are artificial brain chemicals that can help improve mental performance in people. They have grown in favor of today’s world and are usually used to support improvement in concentration, memory, imagination, intelligence, and overall cognitive performance.

Nootropics can generally be divided into three categories, i.e., prescription drugs, synthetic substances, and dietary supplements. Let us take our attention to the Best Nootropic Supplements of 2023:

Oweli Neuro

Best Nootropic 1

Product Overview
Core Ingredients DMAE, L-Glutamine HCL, Bacopa Extract, Bilberry Extract, GABA, DHA, Huperzina A, and more
Servings Per Container 30 days
Money-Back Guarantee 365-day
Price $30

Oweli Neuro is one of the best nootropic supplements on the market whose synergistic nootropic formula has been made using powerful ingredients like DMAE, L-Glutamine HCL, Bacopa Extract, Bilberry Extract, GABA, DHA, Huperzine A, etc.

One bottle of the Oweli Neuro nootropics and smart drugs contains 60 capsules. The makers of this best nootropics supplement suggest its users consume two pills regularly to optimize brain health significantly and target inflammation in the human brain.

The consumption of these brain pills in the recommended dosage helps boost brain function, improve brain health, boost mental energy and mental processing speed, support peak mental performance, improve memory, reduce age-related cognitive decline, and increase cognitive function.

Nuzena Neuro Focus+

Best Nootropic 2

Product Overview
Core Ingredients Maritime pine bark extract, DMAE bitartrate, green tea extract, bilberry fruit extract, and others.
Servings Per Container 30 days
Money-Back Guarantee N/A
Price $30

Nuzena Neuro Focus+ is in this list of the best nootropic supplements due to its high-quality and highly potent nootropic stack formed using ingredients like green tea extract, amino acid, etc. The formulation of this nootropic stack is non-GMO, hormone-free, and sugar-free.

One bottle of the Nuzena Neuro Focus+ nootropic supplement contains 60 veggie capsules. The makers of these natural nootropics and smart drugs suggest its users consume two pills daily to regenerate healthy brain cells and boost brain health significantly.

The consumption of this brain pill, as per dosage guidelines, helps improve mental function, support peak mental performance, increase mental alertness, improve cognitive function, boost cognitive abilities, support peak cognitive performance, and promote the synthesis of brain chemicals.

Nootrogen

Best Nootropic 3

Product Overview
Core Ingredients Glutamic acid, L-tyrosine, amino acids, and DMAE
Servings Per Container 30 days
Money-Back Guarantee N/A
Price $30

Nootrogen is one of the best nootropic supplements on the market whose formulation has been made using amino acid, L-tyrosine, glutamic acid, etc. The formulation of this nootropic stack contains entirely natural nootropics to support your brain health effectively.

One bottle of the Nootrogen nootropic supplement contains 60 capsules in total. All its users are suggested to consume two capsules daily to maintain a healthy brain function by improving the blood flow to the brain.

The consumption of these Nootrogen brain pills helps boost brain power and brain energy, enhance brain function, support brain performance, synthesize brain chemicals, reduce brain fog, regenerate brain cells, protect against cognitive impairment, maintain good mental health, and boost cognitive performance.

Onnit Alpha Brain

Best Nootropic 4

Product Overview
Core Ingredients Huperzia Serrata, Bacopa monnieri, cat’s claw, oat straw, and other botanical amino
Servings Per Container 30 days
Money-Back Guarantee Risk-free money-back guarantee
Price $35

Onnit Alpha Brain is one of the top-rated brain health supplements whose formula is made using power-packed and clinically-studied ingredients like bacopa monnieri, oat straw, cat’s claw, etc. The formulation of these Onnit Alpha Brain nootropic supplements is caffeine-free, nut-free, dairy-free, gluten-free, paleo-friendly, and keto-friendly.

One bottle of the Onnit Alpha Brain nootropic stack contains 90 capsules. The makers of these nootropic supplements suggest their users consume three pills regularly to improve brain function and reduce brain fog.

Upon consumption of these nootropic supplements regularly in the recommended dosage, you will experience an improvement in your overall health. The Onnit Alpha Brain supplements help your brain recover, support, and maintain a healthy brain function, increase blood flow to the brain, boost brain energy, boost brain power, activate your brain chemicals, reduce brain fog, regenerate brain cells, and maintain good brain health.

Qualia Mind

Best Nootropic 5

Product Overview
Core Ingredients Phosphatidylserine, Artichoke leaf extract, Acetyl-L-Carnitine, DL-Phenylalanine, Taurine, Citicoline, Mucuna pruriens, and Theobromine
Servings Per Container 77 days
Money-Back Guarantee 100-day
Price $59

Qualia Mind is one of the best nootropics dietary supplements on the market. This nootropic stack’s powerful and high-quality formulation is 100% natural, non-GMO, gluten-free, and vegan-friendly.

One bottle of the Qualia Mind nootropic supplements contains 154 capsules in total. As per the makers of this nootropic supplement, you should consume two capsules regularly to improve brain function and optimize brain health significantly.

The consumption of these nootropic supplements in the recommended dosage helps improve your brain health, restore the functioning of your brain chemicals, improve mental performance, boost long-term and short-term mental acuity, reduce mental fatigue, boost mental processing speed and mental clarity, support peak mental performance, enhance mental energy, and improve cognitive function.

Qualia Mind is a cognitive enhancer nootropic supplement that also provides several mental benefits – it helps boost cognitive function in people with mild cognitive impairment, reduce cognitive decline, support peak cognitive performance, and maintain good cognitive health.

Vital Plan Brain Boost

Best Nootropic 6

Product Overview
Core Ingredients Bacopa monnieri, Ginkgo Biloba, ashwagandha, cat’s claw extract, and lion’s mane mushroom
Servings Per Container 30 days
Money-Back Guarantee N/A
Price $48

Vital Plan Brain Boost is one of the best nootropic supplements available on the market. These natural brain supplements are formulated using high-quality and highly potent ingredients like bacopa monnieri, Ginkgo Biloba, etc. The powerful formulation of this nootropic stack is caffeine-free, gluten-free, non-GMO, soy-free, and animal-free.

One bottle of the Vital Plan Brain Boost nootropic supplements contains 120 capsules. The makers of these nootropic supplements suggest its users consume four tablets daily for a few weeks to boost cognitive functions, thus making these effective cognitive enhancers.

Upon consumption of these best nootropic supplements regularly in the recommended dosage, you will experience an improvement in your overall physical, mental, and cognitive health. The Vital Plan Brain Boost nootropic supplement and nootropic stack work to boost memory by improving memory retention. It helps increase blood flow to the brain to boost brain function, reduce brain fog, promote brain-derived neurotrophic factors, increase brain power and energy, and improve cognitive function.

This nootropic stack brain pill also helps support healthy brain cells in men and women.

Synapse XT

Best Nootropic 7

Product Overview
Core Ingredients Hibiscus, Hawthorn Berry, Garlic and specific B-Vitamins, Rosemary, Magnesium, and Potassium
Servings Per Container 30 days
Money-Back Guarantee N/A
Price $69

Synapse XT is one of the top-rated brain supplements available on the market, whose formulation is made using goodness-packed ingredients.

One bottle of the Synapse XT nootropic supplement contains 60 capsules in total. The makers of this brain supplement suggest that men and women consume two smart drugs regularly to support hearing, memory, and focus.

Consuming these best nootropic supplements in the recommended dosage helps boost mental energy, reduce mental fatigue, increase mental processing speed, improve cognitive performance, and enhance mental clarity.

These brain supplements also provide several cognitive benefits to the human brain and body. It helps boost cognitive abilities, improve cognitive function, reduce cognitive decline, and boost cognition.

Natural Stacks NeuroFuel

Best Nootropic 8

Product Overview
Core Ingredients Artichoke extract, forskolin, acetyl L-carnitine, vitamin B6, and L-phenylaniline
Servings Per Container 15 days
Money-Back Guarantee N/A
Price $30

Natural Stacks is one of the most popular brands of dietary supplements that aims to bring smart and affordable alternatives to any prescription drug.

NeuroFuel is one such supplement.

It is one of the best nootropic supplements to fuel the Long Term Potentiation in the brain. This allows for memory retention, mental energy, and performance improvement. This is why the makers say you can “Feel The Fuel” when you consume the nootropic supplement.

It is a smart drug that boosts LTP and helps you stay more alert, intellectually curious, and creative than ever.

Mind Lab Pro

Best Nootropic 9

Product Overview
Core Ingredients Maritime pine bark extract, lion’s mane mushroom, citicoline, Bacopa monnieri, Rhodiola Rosea extract, and others
Servings Per Container 30 days
Money-Back Guarantee Empty bottle money-back guarantee
Price $69

Mind Lab Pro is one of our list’s most popular, best nootropic supplements. If you have done some research, you already know that this particular nootropic supplement boasts some of the highest positive reviews.

It has a clean label – no snake oil scams and proprietary formula! Moreover, unlike any prescription drug and numerous dietary supplements, Mind Lab Pro contains all-natural ingredients that boost mental energy, brain function, and memory retention.

One of the reviews says,

“Since using MLP my forgetfulness had receded, and I am able to get a lot more work done. I also find it easier to concentrate and focus for longer bouts of time. Lastly, I sleep better and seldom wake up without being able to go back to sleep.”

Another review for Mind Lab Pro natural nootropics says,

“I have suffered from gastric issues for the past few years. These issues have greatly affected my energy levels and mental outlook on life. Since using MindLab, my energy levels have DRASTICALLY changed, and I love that your product does not have caffeine, as I can not have caffeine because of my gastric issues. Thank you for such a wonderful product.”

Yet another review states,

“It really is as good as they say… all the reviews made me think “there’s no way.” I’ve been taking this for 2 months. 2 capsules a day. I have increased focus. I can stay on task at a higher level. My anxiety is manageable. Even my anger is under control ( really what I was looking for). I honestly feel and am doing better at work. It is pricey, but I bought 4 bottles at once and used PayPal to spread out the payments to make it manageable. Try it. You won’t regret it. I didn’t.”

NooBru

Best Nootropic 10

Product Overview
Core Ingredients Alpha GPC, vitamin B5, L-theanine, ashwagandha, choline bitartrate, Huperzine A, and other proven ingredients
Servings Per Container 20 days
Money-Back Guarantee 100% risk-free guarantee
Price $55

NooBru is one the best nootropics and dietary supplements on the market that promotes the renewal of healthy brain cells while promoting healthy brain function.

It can help you unlock your peak performance and is specially designed to lift your mood and promote creative thinking.

NooBru is double-lab tested; this, in turn, helps ensure you get only the highest quality in terms of ingredients and the overall supplement.

But how does it work so well? Well, all thanks to the brains behind it, who carefully chose science-backed and clinically-proven ingredients that impart all the purported benefits to the supplement.

You can see a noticeable improvement in your cognition upon sustained consumption, especially if you are of “the” age.

Finally, catching up with your smart grandkids doesn’t seem rocket science.

The supplement has a stellar 4.6 rating from thousands of verified users. One of these reviews mentions,

“My parents have really slowed down the last couple of years, and I was looking for something that could help them age more graciously. I saw an ad for Noobru, and they claimed that it would boost your performance and brainpower one drink at a time. I decided to go for it, and I’m sure glad I did. So are my parents. Now they’re chasing the grandkids around, and I even think each of their memories are better than they were a few months ago. I’m completely impressed!”

Another review says,

“It is obvious that nobody likes an aging brain. Poor brain health comes with its cons, such as forgetfulness, irritability, and more. As we all know, an aging brain is a sign of getting old, which means you don’t have much of a choice. However, you can choose to age gracefully with a better brain and a good mood. This can be made possible with NooBru.”

Ageless Brain

Best Nootropic 11

Product Overview
Core Ingredients Bacopa monnieri, cat’s claw, guayusa, Camu Camu, dragon’s blood, cacao, brainpower cinnamon, and others
Servings Per Container 30
Money-Back Guarantee 365-day
Price $55

Nobody likes an aging brain. Poor brain health comes with its cons, such as forgetfulness, irritability, and more. As we all know, an aging brain is a sign of getting old, which means you don’t have much choice.

However, you can age gracefully with a better brain and a good mood. This can be made possible with dietary supplements like Ageless Brain.

Ageless Brain is undoubtedly one of the best nootropics on the market that helps promote healthy brain function and replenishes the brain cells with the nutrition they need.

It is a widely known fact that lifestyle choices, sleep deprivation, smoking, alcohol consumption, poor nutrition, and plenty of other facets can lead to poor brain health. This can lead to poor cognition starting from your mid-30s.

To help prevent something like this from happening, you can take the help of Ageless Brain, a nootropic stack made of nothing but high-quality natural ingredients in a power-packed formulation.

The makers claim that the ingredients are not just barely effective or over-hyped. These ingredients are clinically proven, and if you have never seen the difference with other supplements, Ageless Brain might be the change you want!

It has excellent customer reviews too. Most users seem to have dropped positive reviews claiming that the supplement offered multiple cognitive benefits and could even prevent mild cognitive impairment and sleep deprivation. It also helped treat symptoms of ADHD or attention deficit hyperactivity disorder in several users who continued to use the supplement religiously.

Hunter Focus

Best Nootropic 12

Product Overview
Core Ingredients Bacopa monnieri, Maritime pine bark extract, and phosphatidylserine
Servings Per Container 30 days
Money-Back Guarantee N/A
Price $60

Hunter Focus is one of the best nootropics developed by specialist supplement producer Roar Ambition. The company is based in Leeds, England, aiming to create supplements that will let you achieve the “best” possible.

Roar Ambition offers an extensive range of products, most of which have gained wide popularity among the masses, and Hunter Focus is no different.

This supplement is designed to improve focus and memory retention. If you want to achieve laser-sharp focus, you can count on this supplement to help you achieve it.

This nootropic supplement can work wonders for you with the right lifestyle choices and good nutrition combined.

It also helps promote optimized learning. Although this will sound more appealing to students, learning correctly and retaining information is essential to all, irrespective of age. This is why Hunter Focus works well for every age group.

Thus, Hunter Focus is your supplement to boost energy and elevate your mood and cognitive abilities.

Performance Lab Mind

Best Nootropic 13

Product Overview
Core Ingredients Citicoline, phosphatidylserine, Amino acid, and maritime pine bark
Servings Per Container 15 days
Money-Back Guarantee 30-day
Price $69

Performance Lab is one of the leading producers of dietary products. One of its bestsellers is Mind.

Sounds pretty generic, right?

It isn’t, though! Why? Because Performance Lab Mind is made of some of the best nootropic ingredients available on the market – plus it’s scientifically proven. Research data shows that Performance Lab Mind can boost brain energy by up to 13.6%.

Performance Lab Mind can help you recover from intense cognitive exertion if your work requires extensive mental energy usage. The supplement uses state-of-the-art technology to offer cognitive benefits and is encapsulated in Prebiotic Nutricaps.

These Nutricaps are easy to digest and completely vegan. Moreover, they allow efficient absorption of nutrients in the Mind formula in the blood.

If you have ever experienced stress burnout, you know it’s not pleasant. It can deteriorate productivity, and you will most likely get zero work done if you are mentally burnt out. Performance Lab Mind, one of the best nootropics, helps prevent and cope with stress burnout while aiding attention deficit hyperactivity disorder symptoms.

The supplement boasts excellent customer reviews as well. It is undoubtedly one of the most popular nootropic supplements amongst those looking for a stim-free, vegan, and genuinely potent alternative to prescription brain drugs.

One of the reviews says,

“Love the products so far! I have tried mind, sleep & energy. My mind seems to keep me focused and more in tune with my recall memory. Energy before the gym has saved me from buying pre-workouts now & I can still get a good pump! Sleep gives me vivid dreams and a much deeper REM sleep thus far. I’ve now purchased other variants of your products & can’t wait to try them. Thanks.”

Yet another customer review on the official website mentions,

“I’ve recommended this product to several people. After over a year of using it consistently, it’s still working. Just gives me a little “click” in my brain that helps focus and concentration: as advertised. No stimulants, no jitters. I do cycle off a couple of days here and there, as recommended, and I notice the difference until I get back on a daily dose of Mind!”

NaturalCell NeuroActiv6

Best Nootropic 14

Product Overview
Core Ingredients NeuroFactor (Coffee Fruit), Cognizin (Citicoline), Sensoril (Withania Somnifera) and Activin (Grape Seed), Ginkgo Biloba
Servings Per Container 30 days
Money-Back Guarantee 60-day
Price $46

NaturalCell NeuroActiv6 is one of the best nootropic supplements in powder form whose formulation is sensoril, activin, citicoline, coffee fruit, etc. The formulation of these best nootropics dietary supplements is non-GMO, gluten-free, keto-friendly, dairy-free, and soy-free.

One bottle of the NaturalCell NeuroActiv6 nootropic supplement contains 30 servings in total. The makers of these best nootropics dietary supplements suggest its users consume one scoop of this brain health powder daily to improve memory retention and act as a cognitive enhancer.

The consumption of this nootropic supplement brain pill helps improve brain function and cognitive function, boost mental clarity, reduce cognitive decline and mental fatigue, increase cognition and mental performance, increase mental energy, and boost memory.

NooCube Brain Productivity

Best Nootropic 15

Product Overview
Core Ingredients Alpha GPC, Huperzine A, cat’s claw extract, and Bacopa monnieri
Servings Per Container 30 days
Money-Back Guarantee 60-day money-back guarantee
Price $60

NooCube is one of the best dietary supplements available on the market whose formulation consists of essential vitamins, minerals, and herbal extracts like bacopa monnieri, cat’s claw extract, alpha GPC, etc. The powerful formulation of this natural nootropics supplement is caffeine-free and prescription drug-free.

One bottle of the NooCube Brain Productivity supplement contains 60 capsules. You should consume two capsules daily for a few weeks to boost brain and cognitive function effectively.

The consumption of these nootropic supplements regularly in the recommended dosage helps improve brain function, activate your brain chemicals, and reduce brain fog and cognitive decline.

Other cognitive benefits of these brain supplements are to improve cognitive functions and blood flow to the brain, thus acting as cognitive enhancers significantly.

How Do Nootropics Work? What Is The Science Behind Them?

Nootropics work mainly because of their ingredients. How nootropics work depends on the combined ingredients working mechanisms. Thus, the science behind nootropics also depends on the ingredients used in the supplement.

Thus, to help you understand how well-backed the supplements on our list are, here is an overview of some of the common science-proven ingredients used in most of the nootropics on the list:

Ashwagandha

Ashwagandha (Withania somnifera) is an herb used for centuries in Ayurvedic medicine to treat various conditions, including anxiety, stress, and cognitive decline.

The exact mechanism of how ashwagandha works is not yet fully understood. However, studies have shown that it can increase levels of acetylcholine, a neurotransmitter involved in memory formation and learning.

It may also reduce inflammation in the brain, which can lead to improved cognitive function. Additionally, ashwagandha has been found to increase levels of BDNF (Brain-Derived Neurotrophic Factor), a protein that helps promote neuron growth and survival.

In addition to its potential benefits on cognitive health, ashwagandha has also been found to reduce anxiety and improve mood. This could be due to its ability to reduce cortisol levels in the body, which can help reduce stress and enhance sleep quality.

Overall, ashwagandha appears to be a promising natural remedy for improving cognitive health and reducing anxiety.

Choline

It is an essential nutrient that plays a vital role in brain health. It is a precursor to the neurotransmitter acetylcholine, which is involved in memory formation and learning.

It also helps to maintain the structural integrity of cell membranes, which can help to protect neurons from damage. Additionally, choline has been found to increase levels of BDNF (Brain-Derived Neurotrophic Factor), a protein that helps promote neuron growth and survival.

Studies have shown that choline supplementation can improve cognitive performance in healthy individuals and those with cognitive decline.

Citicoline

The scientific evidence for the benefits of citicoline is promising. Studies have found that citicoline can help to improve cognitive performance, memory, focus, and concentration. It works by increasing levels of acetylcholine, a neurotransmitter that helps transmit signals between neurons in the brain. Additionally, citicoline can help reduce inflammation in the brain and protect it from damage caused by free radicals.

A study published in the journal Nutrients found that taking citicoline supplements for 12 weeks improved cognitive performance compared to those who did not take them. The study also showed that taking citicoline was associated with increased levels of certain neurotransmitters, such as serotonin and dopamine.

Other studies have also shown that it can help improve memory and learning ability in healthy individuals and those with Alzheimer’s disease or other forms of dementia. Additionally, some research suggests that taking citicoline may be beneficial for treating stroke-related cognitive impairments.

Camu Camu

Camu Camu is a small, tart berry native to the Amazon rainforest. It is packed with powerful antioxidants, essential vitamins, and minerals, making it an excellent natural remedy for improving cognitive health.

The high levels of vitamin C in camu camu are especially beneficial for brain health, as they can help to protect against oxidative stress and reduce inflammation.

Studies have also found that taking it can help improve focus and concentration. This is likely due to its high levels of B vitamins, which are essential for healthy brain function. Additionally, the antioxidant properties of camu camu may help protect the brain from damage caused by free radicals.

Overall, camu camu is an excellent natural remedy for improving cognitive health. It can help protect the brain from damage caused by free radicals, improve memory and learning ability, and increase focus and concentration.

Algae

Algae is a group of aquatic organisms that range from single-celled microorganisms to large, complex multicellular forms.

These are found in freshwater and marine environments and can be either autotrophic or heterotrophic. Autotrophic algae use photosynthesis to produce their food, while heterotrophic algae rely on other sources of nutrition.

These are an essential part of the global ecosystem, providing oxygen and food for many aquatic species.

In addition, some types of algae have been used for centuries in traditional medicine due to their health benefits.

Research has recently shown that certain algae types may also benefit cognitive health.

Studies have found that consuming certain types of algae can help to improve memory and learning ability. This is likely due to the high omega-3 fatty acids in some algae, which are essential for healthy brain function.

Additionally, some studies suggest that consuming certain types of algae may help protect against age-related cognitive decline by reducing inflammation in the brain and protecting it from damage caused by free radicals.

Maritime Pine Bark Extract

Maritime pine bark extract is a natural supplement derived from the bark of the maritime pine tree. It has been used for centuries in traditional medicine due to its health benefits, and more recently, it has gained attention for its potential cognitive-enhancing effects.

The active ingredient in maritime pine bark extract is pycnogenol, a powerful antioxidant that can help protect the brain from damage caused by free radicals. Additionally, it contains procyanidins, compounds that have been shown to improve memory and learning ability.

Studies have also found that taking maritime pine bark extract can help reduce inflammation in the brain, which may be beneficial for treating age-related cognitive decline. Additionally, some research suggests that it may help improve focus and concentration by increasing dopamine and serotonin levels in the brain.

Pinene is another active ingredient found in maritime pine bark extract that has been shown to have numerous health benefits. Pinene is a terpene, a type of organic compound found in many plants. It has a strong aroma and flavor and is known for its anti-inflammatory, antioxidant, and neuroprotective properties.

Studies have shown that pinene can help protect the brain. Additionally, it may help improve memory and learning ability by increasing levels of acetylcholine in the brain. Acetylcholine is an important neurotransmitter involved in memory formation and recall.

GABA

GABA (gamma-aminobutyric acid) is an inhibitory neurotransmitter that plays a crucial role in regulating neuronal excitability throughout the nervous system. It works by binding to GABA receptors on neurons, which reduces their activity and helps to maintain balance in the brain.

It has been shown to have calming effects and is often used as a supplement to help reduce anxiety and promote relaxation. Additionally, some research suggests that it may help improve cognitive function by increasing dopamine and serotonin levels in the brain.

A systematic review of the effects of GABA supplementation on cognitive performance found that it may help improve attention, memory, and learning ability. The study included 11 randomized controlled trials with a total of 518 participants.

The results showed that GABA supplementation was associated with improved cognitive performance in all domains tested, including reaction time, working memory, and executive function. The authors concluded that GABA could be an effective supplement for improving cognitive performance in healthy adults.

Lion’s Mane Mushroom

Lion’s mane mushroom (Hericium Erinaceus) is an edible mushroom used in traditional Chinese medicine for centuries. It is known for its medicinal properties and health benefits, including its ability to improve cognitive function.

Studies have found that lion’s mane mushroom can help increase nerve growth factor (NGF) levels, a protein involved in the growth and maintenance of neurons.

Lion’s mane mushroom has also been shown to improve memory, focus, and concentration by increasing levels of acetylcholine and dopamine in the brain.

The active compounds in lion’s mane mushrooms are polysaccharides, complex carbohydrates that have been shown to have neuroprotective effects. These polysaccharides can help protect the brain from damage caused by free radicals and inflammation, leading to age-related cognitive decline.

Ginkgo Biloba

It is an herbal supplement used for centuries to promote brain health. It is derived from the leaves of the Ginkgo biloba tree, which is native to China.

It contains various active compounds, including flavonoids and terpenoids, known for their antioxidant and anti-inflammatory properties.

Scientific studies have shown that Ginkgo biloba can help improve cognitive performance by increasing blood flow to the brain and providing more oxygen and nutrients to neurons. This increased blood flow can also help reduce fatigue and mental fog associated with aging or stress.

In a study of healthy adults, Ginkgo biloba improved memory, concentration, and reaction time.

B Vitamins

B vitamins are a group of water-soluble vitamins that play an essential role in many bodily functions, including energy production, brain health, and the formation of red blood cells.

They include thiamine (vitamin B1), riboflavin (vitamin B2), niacin (vitamin B3), pantothenic acid (vitamin B5), pyridoxine (vitamin B6), biotin (vitamin B7), folate (vitamin B9) and cobalamin (vitamin B12).

These vitamins are essential for maintaining healthy nerve cells and helping to produce neurotransmitters such as serotonin and dopamine. They also help convert food into energy and support a healthy immune system.

Two scientific studies have shown that B vitamins can help improve brain health. An analysis of healthy adults found B vitamins to improve memory, concentration, and reaction time.

They may also help protect the brain from damage caused by free radicals and inflammation, which can lead to age-related cognitive decline.

Another study on 41 elderly patients found that B vitamins improved cognitive performance, including memory and executive function.

Bacopa Monnieri

Bacopa Monnieri is an herb used for centuries in Ayurvedic medicine to improve cognitive health. It increases neurotransmitters in the brain, such as serotonin and dopamine. This helps to improve memory formation, learning, and concentration.

Additionally, it has been found to reduce anxiety and depression, which can help with mood regulation. It also increases blood flow to the brain, which can help with mental clarity and focus. Finally, it may help protect against age-related cognitive decline by reducing inflammation in the brain.

Additionally, it has been found to reduce anxiety and depression by modulating GABA (gamma-aminobutyric acid) activity in the brain. GABA is a neurotransmitter that helps regulate mood and stress levels.

Increasing GABA activity, Bacopa Monnieri, can help reduce anxiety and depression symptoms. Finally, it may help protect against age-related cognitive decline by reducing inflammation in the brain.

Turmeric

The active ingredients in turmeric are curcuminoids, a group of compounds with potent anti-inflammatory and antioxidant properties.

Curcumin is the most abundant curcuminoid in turmeric and is responsible for many of its health benefits. It has been shown to reduce inflammation, improve cognitive function, protect against oxidative damage, and even help prevent Alzheimer’s disease.

Additionally, it may help reduce anxiety and depression by modulating GABA activity in the brain.

Studies have shown that curcumin and Bacopa Monnieri can help improve cognitive health.

A study published in the journal Phytotherapy Research found that taking a combination of curcumin and Bacopa Monnieri for 12 weeks significantly improved memory, attention, and reaction time in healthy adults.

Another study published in the journal Evidence-Based Complementary and Alternative Medicine found that taking a combination of curcumin and Bacopa Monnieri for eight weeks improved cognitive performance, including memory and executive function, in elderly patients.

Finally, a study published in the journal Neuropsychopharmacology found that taking a combination of curcumin and Bacopa Monnieri for 12 weeks reduced anxiety and depression symptoms by modulating GABA activity in the brain.

Ranking Factors That Helped Us Pick The Best Nootropic Supplements

If you have tried looking up the best nootropics, you know it is pretty daunting. Why? Because every famous (and unpopular) brand in the supplement industry has come up with its line of “natural nootropics.” The problem with this is that most of these so-called brain supplements don’t work and are most likely showing up on your search results because brain supplements are the trend right now.

This is why we did thorough research and came up with this list of the article’s best nootropics and smart drug supplements.

The question is, how did we come up with the list? To answer that question, we picked specific parameters on which we compared hundreds of supplements to see if they passed these parameters.

So, what are these parameters? Let’s have a look below:

Use Of Natural Ingredients

The first and foremost metric we used to rank the best nootropics for this list was the usage of natural ingredients. No smart drug on our list contains synthetic, banned, or harmful components.

On top of this, we also looked at the kind of natural ingredients used by the best nootropics we selected for our list. Our researchers thoroughly analyzed the brain supplements and read the fine print to understand if the supplements contained potent and scientifically-proven ingredients.

Ginkgo Biloba was one of these ingredients that we found predominantly used in some of the best nootropics. Another ingredient in the brain pills on our list was bacopa monnieri, clinically proven to prevent mental fatigue, improve mental clarity, and boost the production of brain chemicals.

We made sure to pick only those brain pills and nootropic supplements that used potent, highly-effective, cleanly-sourced natural ingredients that helped boost mental function and improve cognitive processing.

Money-Back Guarantee Offered

When it comes to trying out a cognitive enhancer or any other dietary supplement for that fact, any genuine buyer will be skeptical before spending their money.

But, let’s say a user put their mind to a specific cognitive enhancer and makes the purchase. However, even upon continued usage, the smart drug didn’t work as well as it claimed. This can leave the user in a lot of disappointment and paranoia towards trying other cognitive enhancers.

However, a company can strengthen the user’s trust in its brand by offering a money-back guarantee. This way, the user can make the purchase, knowing they can claim their money back if the supplement does not work out as it was supposed to.

This is why most of the brain supplements on our list offer some money-back guarantee to let their users try the product and see if it works out for them. Most companies usually have a 60-day money-back guarantee. However, some are confident enough to offer a guarantee as high as 90 days or even 365 days.

Working Mechanism

The working mechanism of a smart drug is important because it determines how well the brain pill will work. This is why all of the best nootropic supplements on our list have science-proven mechanisms that work uniquely to promote cognitive functions, prevent mental fatigue, improve memory, boost memory retention, and provide other cognitive benefits.

Many cognitive enhancers also boost the number of brain chemicals while supporting healthy brain cells.

Affordability and Value For Money

It is a common notion that effective supplements must be heavy on the pocket. No! They don’t.

Most of the best nootropics on our list are pretty pocket-friendly and affordable. Although some of the supplements above may come off as slightly pricey, we can certainly bet that they offer value for money by using the most premium ingredients sourced from the remotest places in the world.

Thus, regardless of your budget, our list has a smart drug or brain pill that fits your price expectations.

Dosage

Apart from looking at the usage of natural ingredients, we also looked at the dosage of these ingredients in a natural nootropic supplement. The dosage of individual components in a brain pill is essential because if the elements are underdosed, they may not work well, regardless of their effectiveness. On the other hand, if the ingredients are incorporated in a dosage way over the clinically safe limit, it can be harmful to human consumption.

Thus, we included only the best nootropics with the proper dosage for each ingredient.

Customer Reviews

All the nootropic supplements discussed in the listing have gained multiple customer reviews.

A verified customer says in his review,

“One of my friends suggested that I take nootropic supplements. Since they were in the mainstream, I thought to give them a try. I had been suffering from various cognitive issues, and the supplements worked wonders! These supplements helped me to get mental clarity and stay focused while performing daily tasks.”

One of Qualia Mind Supplements’ reviews states,

“Absolutely the best! These supplements actually serve what they promise. Been using them for about two weeks now, and I am noticing maximum improvement in my cognitive function. I recommend everyone facing trouble with their mental performance to stand behind the best nootropics.”

The Best Nootropic Supplements for 2023 Final Verdict

As we saw above, a brain pill can be worth the cost, time, and effort put into it if you only know how to incorporate it effectively into your daily life. By this, we mean to say that you should treat a brain supplement for what it is – a supplement. Thus, focus on proper nutrition and healthy lifestyle choices to improve memory and brain performance while eliminating brain fog. Try a top nootropic supplement above today!

Note: The information presented above is informative and does not intend to substitute medical advice. Before starting supplementation of any dietary supplement, make sure to consult with a medical professional.

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The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team. Please know we only recommend high-quality products.

Disclaimer:

Please understand that any advice or guidelines revealed here are not even remotely substitutes for sound medical or financial advice from a licensed healthcare provider or certified financial advisor. Make sure to consult with a professional physician or financial consultant before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary and are not guaranteed as the statements regarding these products have not been evaluated by the Food and Drug Administration or Health Canada. The efficacy of these products has not been confirmed by FDA, or Health Canada approved research. These products are not intended to diagnose, treat, cure or prevent any disease and do not provide any kind of get-rich money scheme. Reviewer is not responsible for pricing inaccuracies. Check product sales page for final prices.

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