5 Best NMN Supplements (2023 update)

Anti-aging supplements are very popular right now and NMN is one of the best-known ingredients in this space. NMN belongs to a group of supplements also known as NAD+ boosters. 

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It’s no surprise that the interest in NMN supplements is rising given the likes of Harvard University professor and longevity expert David Sinclair claiming he takes it daily.

But with so many brands on the market, it can be hard to know which NMN supplement is right for you.

In this article, we’re going to pick out the best NMN supplements available right now based on purity, quality, and price.

How to pick a top NMN supplement

There are only a few things to look out for when picking an NMN supplement. It may seem daunting at first, but with a little bit of knowledge, it’s easy to pick out the best NMN supplements by simply looking at the labels.

Purity 

98% purity NMN is the benchmark level you should be looking for. If the label doesn’t clearly state this as a percentage, it usually means the exact purity is unknown.

Dose 

NMN is a dietary supplement so there is no specific recommended dose. The products on the market base the dosing on what’s used in research studies. To complicate things, a wide range of doses are often used in studies from 250mg to over 1000mg. With that said, the best NMN supplements stick to a range of 250 to 500mg because this dose has the lowest side effect profile, whilst still having an impact.

Quality 

If you look closely at any labels, you’ll notice that there are “other ingredients” listed below the supplement facts table. During the manufacturing process, small amounts of inactive ingredients are added to prevent the machines from getting stuck. These are called “flow agents”. The top NMN supplements avoid the use of magnesium stearate or silicon dioxide. These are also used to pack empty spaces in capsules to make them look more full.

Manufacturing standards

Manufacturers in the US and Europe must comply with good manufacturing practices (GMP) and also have inspections by regulatory agencies such as the FDA. It’s unusual to come across supplements that are not made in a GMP or FDA-registered facility. But it’s something to be aware of just in case.

With the above in mind, let’s get straight into the best NMN supplement brands.

The 5 Best NMN supplements review

You may notice that many brands combine NMN with Resveratrol as this is another well-known NAD booster. Aside from NMN, there are actually several NAD-boosting ingredients so the best NMN brands often put them together to reduce the number of pills you have to take.

1) Omre NMN + Resveratrol + Bioperine

Nmn Supplements 1

Purity and dose (2 capsules serving size):

  • NMN 500mg – 98% purity
  • Resveratrol 500mg – 98% purity
  • Bioperine (piperine) 5mg – 98% purity

Quality:

  • Maximum purity ingredients
  • Made in the USA
  • No magnesium stearate or silicon dioxide
  • 3rd party tested
  • Vegan capsule
  • Added Reseveratrol + Bioperine

Price:

$44.97

OMRE NMN + Resveratrol is a top NMN supplement that contains maximum purity NMN at a 500mg dose per serving. Alongside this, it also contains Resveratrol which is another well-known NAD booster, and Bioperine which helps increase bioavailability. OMRE does not contain any artificial fillers or flow additives and is made in the USA.

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2) Genex Formulas NMN 500

Nmn Supplements 2

Purity and dose (3 capsule serving size):

  • NMN 500mg – 98% purity

Quality:

  • Made in the USA
  • 3rd party tested
  • Vegan capsule
  • No magnesium stearate or silicon dioxide

Price:

$59.11

Genex comes in a few different doses. Their original formula contains 250mg of NMN and as the name alludes to, the NMN 500 contains 500mg. This is another best-selling NMN supplement with high-purity NMN without any artificial additives.

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3) Toniiq NMN + Resveratrol + Betaine Anhydrous

Nmn Supplements 3

Purity and dose (3 capsule serving size):

  • NMN 500mg – 98% purity
  • Resveratrol 500mg – 98% purity
  • Betaine Anhydrous 500mg – 98% purity

Quality:

  • Maximum purity ingredients
  • 3rd party tested
  • Vegan capsule
  • Added Reseveratrol + Betaine Anhydrous

Price:

$44.97

Toniiq is one of the best-known brands on Amazon and sells lots of different supplements including NMN. In their Elixir product, they include NMN, Resveratrol, and Betaine anhydrous. They do however use magnesium stearate and silicon dioxide which some people may prefer not to have in their choice of NMN supplement.

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4) Double wood NMN

Nmn Supplements 4

Purity and dose (2 capsule serving size):

  • NMN 250 – 98% purity

Quality:

  • Made in the USA
  • 3rd party tested
  • No magnesium stearate or silicon dioxide

Price:

$48.95

Double wood supplements are arguably one of the most well-known brands on Amazon having been around for many years. With that comes experience and quality supplements. Double wood NMN uses gelatin capsules so it wouldn’t be suitable for vegans or vegetarians. Also, the other thing to factor in is that the dose is lower per serving than the products mentioned above.

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5) Peak Performance NMN + Resveratrol

Nmn Supplements 5

Purity and dose (2 capsule serving size):

  • NMN 150mg – 98% purity
  • Resveratrol 150mg

Quality:

  • 3rd party tested
  • Vegan capsule

Price:

$39.95

Peak performance is another top NMN brand in the longevity space. It’s made in the USA and 3rd party tested to confirm the dose and purity. The dose of NMN is relatively smaller compared to the other supplements listed here but this also means it’s priced slightly cheaper.

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What is NMN?

NMN is short for nicotinamide mononucleotide which is a direct precursor to NAD. This means our cells use NMN to make NAD. And several studies have shown that NMN supplementation has the potential to increase NAD levels. Hence why NMN is commonly grouped into a category of supplements called “NAD boosters”.

So you may be asking, what is NAD and why is it important?

NAD is the universal energy currency of our cells. It’s the fuel our cells use for myriad essential processes such as DNA repair, energy metabolism, and gene expression to name a few.

Researchers such as the likes of David Sinclair and his colleagues have shown in various animal studies that declining NAD levels are linked to aging. They’ve also shown that boosting NAD levels with NMN (and other compounds such as Resveratrol) can slow down or reverse aging at a cellular level. (1)

Naturally, the next question is usually: why can’t you take NAD directly? Why do you need to take NAD precursors like NMN?

The reason is, NAD is a large molecule and can’t be absorbed into the bloodstream and then into your cells directly. If you take NAD directly, it’s simply broken down in your guy into its constituent parts and then rebuilt again by your cells. This process is far less efficient and effective than taking a precursor like NMN.

Is NMN the same as vitamin B3?

To answer this question, we need to go into the chemistry of NMN and NAD.

NAD is essentially 2 NMN molecules put together.

NMN is made up of 3 parts:

  1. Vitamin B3
  2. Sugar
  3. Phosphate

To make NAD, our cells first combine vitamin B3 and sugar. The next step is adding phosphate to form NMN.

So to answer the question, NMN is not the same thing as vitamin B3. Vitamin B3 is one of the 3 building blocks required to make NMN.

Which is better: NMN or NR?

Now, this is a highly contentious area of longevity science and there’s a lot of debate around this topic.

First of all, what is NR (Nicotinamide Riboside)?

If you go back to the last section, we explained the steps toward making NAD include:

Step 1: Vitamin B3 + Sugar (this compound is called NR)

Step 2: Vitamin B3 + Sugar + Phosphate (This compound is called NMN)

Step 3: NMN + NMN = NAD (two NMNs combined make one NAD)

Therefore, NR is the precursor to NMN.

As late as 2019 / 2020, there were no good human studies looking into NMN as a NAD booster in humans. Whereas a lot more research was available for NR. That led lots of people to prefer NR over NMN.

However, the latest research shows that NMN is just as good, if not better than NR at boosting NAD levels. (2)(3)

Most of the top scientists in the longevity field believe that NMN is superior because it’s only one step away from the process of forming NAD. The theory is that the less work your cells have to do, the easier and more efficient the production of NAD. That’s why NMN is thought to be a superior option. With all that said, the jury is still out and more research is needed.

What are NMN supplements good for?

The research into NMN supplements and their potential health benefits is very much in its early stages. Although it’s been studied in animals for longer, human studies have only been carried out in the last few years.

Therefore, the information in this section should not be taken as scientific fact because a lot more research needs to be done before the benefits of NMN are fully proven.

Potentially slows down cellular aging

Taking NMN supplements to slow down or reverse cellular aging is being intensely investigated in the scientific world.

In fact, essentially all of the benefits of NMN can be linked back to its anti-aging properties in some way.

To put it simply, NMN supplements boost NAD levels and high levels of NAD activate sirtuins. Sirtuins are proteins that have many crucial functions such as DNA repair, regulating inflammation, and cell metabolism.

There is good evidence that NAD levels decline with age and therefore sirtuin regulation is impaired. This has a knock-on effect on all the hallmarks of aging which include things such as DNA instability, ineffective control of inflammatory pathways, and mitochondrial dysfunction.(4)

Boosting NAD levels using NMN has been shown to increase NAD levels and improve the hallmarks of aging in yeast, flies, and mice. On a similar note, taking NMN has been shown to increase NAD levels in humans as well. But whether it has the same impact on aging is yet to be determined. (5)

Potentially improves cognitive function in elderly

Scientists are looking at the potential role of NMN supplements in improving brain health and function. In particular in the field of dementia.

There are a handful of animal studies that have looked at how feeding NMN supplements to animals has a positive impact. For example, the improvement of blood flow in the brain and reducing the number of abnormal proteins that build up in Alzheimer’s. (6)

However, it’s very early days in terms of research and we’ll know a lot more in the years to come.

Potentially improves aerobic capacity and muscle function

A double-blind placebo-controlled trial in 2021 looked at giving NMN supplements to amateur runners. They showed that the runners given NMN over a 6-week period had a better aerobic performance. The researchers suggest that this is probably because NMN increases the utilization of oxygen by muscle cells. (7)

Potentially improves insulin sensitivity

Insulin sensitivity is one of the hallmarks of aging. As we get older, our cells become less sensitive to the action of insulin.

The damaging effects of this are played out clearly in people with uncontrolled diabetes. Chronically high glucose causes damage to blood vessels and nerves which is one of the primary underlying reasons for all the cardiovascular and neurological risks associated with this condition. In essence, low insulin sensitivity and therefore higher blood glucose levels speed up the aging process.

Studies have shown that NMN supplements could improve insulin sensitivity in muscle cells and are seen as a possible natural option for keeping sugar levels in check. (8)

What is the best dose of NMN to take?

We mentioned earlier that NMN has only entered human trials in the last few years. So the information on the best dose of NMN to take is limited.

Also, everyone is different and the optimum dose of NMN will be different for everyone. Things like your weight, age, and general health will probably have an impact.

With that said, most human research studies use doses of between 200mg to 1500mg. The most common dose used is around the 500mg mark.

Furthermore, dietary supplements like NMN do not have a “daily value” (DV) set out by the FDA. That’s because it is not an essential nutrient. Therefore, an official recommended dose from a regulatory body such as the FDA will not be released.

For these reasons, you will need to do your own research and testing to see what suits you the best.

NMN side effects

Before we start this section It’s important for us to stress that the studies mentioned in this article are very small compared to proper drug trials where thousands of people are enrolled. In addition, long-term studies have not been carried out on NMN. Furthermore, everyone is unique and could react differently to a dietary supplement they’ve not tried before. Therefore, it’s really important you discuss this with your doctor. This is especially pertinent if you have any health problems or are taking any regular medications.

On that note, there are several studies that have reported no or minimal side effects when NMN is given daily at a dose below 1000mg. A study published in August 2022 gave 1250 mg of NMN for 4 weeks in 31 healthy adult men and women aged 20-65 years. They reported no severe adverse events and that NMN was generally well-tolerated. They also reported no abnormal changes in blood and urine markers. (9)

As we mentioned above, there isn’t enough data in large safety trials to say that NMN is without any risks or side effects. As always, speak to your doctor first.

Which NMN brand does David Sinclar use?

Dr. David Sinclair has publicly said he takes 1000mg of NMN along with 1000mg of Resveratrol a day. On your quest for the best NMN supplement, you may be thinking that you’ll just go with a brand that he picks. After all, with the amount of knowledge he has in the field, he’s probably going to be highly selective.

Unfortunately, Dr. Sinclar doesn’t endorse any particular NMN supplement. He only recommends checking to ensure it’s 98% purity and made by a reputable brand.

NMN FAQ’s

Next up, we’ll go over all the most commonly asked NMN-related questions on the internet.

Can NMN cause weight gain?

The quick answer is no, it does not. In fact, it may have the potential to do the opposite. As we age, we put on weight easier which will resonate with many people reading this article.

This is partly because our muscles are less metabolically active and our cells become more insulin resistant with age.

As we highlighted in the section above, NMN has been shown to increase muscle cell metabolism and improve insulin resistance. A study showed that NMN supplementation prevented age-associated weight gain. (10)

Don’t confuse this with meaning that NMN supplements are good for weight loss!

What happens when you stop taking NMN?

There are no withdrawal effects when you stop taking NMN. It’s not like certain medications that have adverse effects when you stop taking them.

NMN is basically Vitamin B3 + sugar + phosphate. Your cells produce it naturally. NMN supplements just boost NAD levels. So when you stop taking it, you’ll just go back to your usual rate of NAD production.

Does NMN regrow hair?

There are lots of anecdotal reports that taking NMN has helped people with hair growth and thickness. But at the time of writing, there isn’t much concrete evidence from scientific research.

One study looked at injecting NMN along with two other growth factors into the scalp which showed some improvement in hair growth. (11)

Clearly, this is not comparable to taking NMN supplements orally. In summary, we don’t know yet if NMN has any benefits for hair growth.

At what age should you start taking NMN?

NAD levels have been reported to drop in blood, skin, and cerebrospinal fluid as early as people in their 20s. With that said, there’s more of a marked difference when comparing younger aged people (20-40) with older age groups (over 65). (12)

With this in mind, there is no specific age you should start taking NMN. It ultimately depends on your personal circumstances.

Naturally, people start to become interested in age-related science as we get into our middle ages and start to feel the effects of aging. This is the stage people often start taking NMN supplements.

Scientists in the field would argue that getting in front of aging as soon as possible is the best approach. Not just in relation to taking supplements like NMN but also with other factors that impact longevity such as a low-calorie diet and high-intensity exercise.

Is NMN worth taking?

NMN supplements are expensive and you may be thinking, is it actually worth taking in the long term?

It’s a simple question that doesn’t have a straightforward answer. Seeing as the research into NMN and age-related decline is very new and still developing, there is an element of risk vs reward.

It is certainly true that the benefits of NMN in humans are not a proven science yet. It’s shown promise in animal studies but this is not directly transferable to humans. Some people may prefer to wait for more robust trials to be published, but this could take another 10-20 years.

Why do brands combine NMN and Resveratrol together?

You may have noticed online that the best NMN supplements combine the two ingredients together. But why is this the case?

Resveratrol was one of the first compounds identified to have cell life-extending properties. Dr. Sinclar and his research group first saw this in yeast cells in 2003.

They found that feeding resveratrol to yeast cells significantly prolonged their life. Further research found that Resveratrol does this by indirectly increasing the amount of NAD produced in the cells.

In other words, Resveratrol is considered to be a NAD booster and that’s why the best NMN brands combine them together so that you don’t have to take so many pills.

Is NMN better in powder or capsules?

In short, there is no difference. They are effectively the same thing. NMN capsules are basically NMN powder packed into a shell.

NMN powder is often slightly cheaper than capsules. That’s because it’s cheaper to manufacture as it doesn’t need to go through all the machinery required to pack pills.

On the other hand, NMN capsules are a lot more convenient because you don’t need to mix them in your food or water. Although NMN doesn’t taste of much, most people would rather not force down a chalky drink in the morning. Ultimately, it just comes down to personal preference!

What time of day is it best to take NMN?

NMN is best taken in the morning. The reason is, there is a natural rise in cellular NAD production in the mornings. In other words, NAD production follows a circadian rhythm.

It’s not to say that taking it in the evening is detrimental or bad. It’s just less likely to have as much of an impact. It’s always best to follow your body’s natural rhythm.

Do you have to take NMN on an empty stomach?

Unlike many other supplements, NMN is actually relatively easily absorbed from the gut. This is the case even on an empty stomach. So you don’t need to take it with food necessarily.

There are lots of articles that say NMN is poorly absorbed with low bioavailability. But this is not what the studies say. There are a number of human studies which show that NMN levels increase in blood and lead to increase an increase in NAD levels with oral administration.

Which form of NMN is best?

In your search for a top NMN supplement, you may have come across various forms of NMN such as lozenges, sublingual tabs, liposomal NMN, and your standard powder and pills. All of which claim to be the best forms of NMN.

As we explained in the previous section, NMN capsules and powder are well absorbed from the gut into your bloodstream, even on an empty stomach. So there may not be a need to convert the NMN into a different form to improve its absorption.

At the time of writing, there are no proper trials that have confirmed that one form of NMN is better than another. Therefore, you may be spending more than you need to if you choose to go for a more expensive form.

Which foods contain high NMN?

If you’re thinking of trying to get more NMN through your diet, here is a list of NMN-rich foods. (13)

  • Avocados: 0.36 to 1.60 mg per 100 grams
  • Broccoli: 0.25 to 1.12 mg per 100 grams
  • Cabbage: up to 0.9 mg per 100 grams
  • tomatoes: 26 to 0.30 mg per 100 grams
  • raw beef: 0.06 to 0.42 mg per 100 grams

You may have noticed that the amount of NMN in foods is a fraction of that you can obtain through NMN supplements. As we mentioned earlier, the best NMN supplements contain a dose of around 250mg – 500mg. That would you would need to have around 250-500 avocados to get the same amount of NMN.

Unfortunately, you can’t realistically get a high enough dose of NMN from food sources.

The best NMN supplements – Final words

There you have it, we’ve come to the end of our look into the best NMN supplements on the market.

It’s important to appreciate that not all NMN supplements are the same. There could be a big difference in quality and dose depending on which brand you opt to go for.

Aside from this, it’s important to emphasize that the research into NMN and its impact on aging is very much in the early stages. Although animal studies are promising, It’s far from a proven science.

With all that said, if you want to invest in a brand, you can’t go wrong with any of the best NMN supplements mentioned in this article.

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