Best Joint Supplements: Top Healthy Joint Pain Relief Support Pills


Due to individuals’ busy and unhealthy lifestyles these days, the problem of joint stiffness and joint discomfort leading to severe joint pain has become common. Therefore, the use of joint supplements is becoming prevalent these days by men and women to support joint health, improve joint function, and treat joint pain effectively with the help of their potent formulations.

But, it becomes difficult for users to choose the best supplements for joint health from the plethora of joint pain supplements available on the market from different companies, as not all have proven health benefits. Thus, to solve this issue and help consumers, our research team has curated this list of the best joint supplements.

The Top 10 Best Joint Supplements Of 2023

This section will review joint support supplements by companies with proven health benefits for men and women. Below is a detailed description of the top 10 joint health supplements:

  • BioTRUST Joint 33X
  • PureHealth Research Joint Support
  • PhytAge Labs Joint Relief 911
  • Zenith Labs Joint N-11
  • ProJoint Plus
  • 1MD MoveMD
  • Nuzena Joint Support +
  • Thrive Health Labs Joint Guard 360
  • Onnit Joint Oil
  • UpWellness Golden Revive +

BioTRUST Joint 33X


  • Key Ingredients: UC-II, Mobilee, and AprèsFlex
  • Side Effects: No adverse effects
  • Money-Back Guarantee: 60-day
  • Pricing: $49
  • What Makes BioTRUST Joint 33X Stand Out: This joint supplement stands out from the others on the market because its formulation helps support optimal joint health in men and women significantly.

Supplement Description

BioTRUST Joint 33X is the best joint supplement on the market, providing numerous health benefits to men and women. This joint supplement is better than others, as it has an advanced 3-in-1 joint health formula.

These BioTRUST Joint 33X joint health supplements combat collagen wear and tear, protect against enzyme attack and lubricate your joints with the goodness of three key natural ingredients.

This 3-in-1 formula helps treat mobility-related joint discomfort by relieving joint pain, thus helping you maintain long-term joint health effectively. This anti-inflammatory formula helps reduce knee pain, eliminate the risks associated with rheumatoid arthritis foundation and knee osteoarthritis, and reduce joint inflammation.

A BioTRUST Joint 33X user review on its official website reads,

“I bought Joint 33X, and now I am doing much better. My legs and back were in a lot of discomfort, and now, since I have been taking this, I am feeling like a brand-new person.”

This one of the best supplements for joint pain has been manufactured by BioTrust Nutrition which is a trusted American online nutrition brand for its dietary supplements. The team of medical researchers and nutrition experts from this brand has designed the advanced 3-in-1 formula of this supplement in state-of-the-art facilities.

PureHealth Research Joint Support


  • Key Ingredients: Resveratrol, Boswellia serrata, type II collagen, omega-3 fatty acids, and others
  • Side Effects: No side effects.
  • Money-Back Guarantee: 365-day
  • Pricing: $58
  • What Makes PureHealth Research Joint Support Stand Out: This best joint supplement helps support men and women facing joint mobility and connective tissue issues.

Supplement Description

PureHealth Research Joint Support is one of the top natural joint supplements on the market that several users have loved because of its potent formula that helps support your cartilage and joint health.

This medical doctor-formulated natural supplement is additive-free and non-GMO, thus making it one of the best turmeric supplements. It has been manufactured in a state-of-the-art facility following all necessary safety guidelines and is available on the market in capsule form.

Several PureHealth Research Joint Support reviews from customers mention that this turmeric supplement has helped them in treating joint pain or arthritis pain effectively. It has helped reduce joint swelling, reduce inflammation, eliminate the risks associated with arthritis foundation, support bone health, and reduce pain.

This best joint supplement has been designed and formulated by Dr. Holly Lucille and her team of medical researchers at PureHealth Research. They have made these anti-inflammatory capsules power-packed by adding turmeric and omega-3 fatty acids for treating arthritis pain.

PhytAge Labs Joint Relief 911


  • Key Ingredients: Andrographis Paniculata, hyaluronic acid, rice powder, and others
  • Side Effects: No adverse effects.
  • Money-Back Guarantee: 90-day
  • Pricing: $69.95
  • What Makes PhytAge Labs Joint Relief 911 Stand Out: This joint supplement stands out from others in relieving pain in the joints on the market due to its formulation that helps maintain healthy joints in men and women significantly.

Supplement Description

PhytAge Labs Joint Relief 911 is among the best organically formulated to support men’s and women’s joint, knee, nail, and bone health. It contains two key ingredients: hyaluronic acid and Andrographis paniculata per serving.

It is an all-natural, cruelty-free, and non-GMO joint supplement in capsule form made in the USA. You can consume two of these anti-inflammatory capsules daily with a meal for treating joint pain.

The makers of this one of the top supplements for joint pain are a group of learned health professionals, nutrition experts, and scientific minds at PhytAge Laboratories who have made this powerful formulation for men and women to help relieve joint pain, reduce joint inflammation, eliminate the risks associated with knee osteoarthritis, maintain strong bones, and improve joint mobility.

Zenith Labs Joint N-11


  • Key Ingredients: Niacin, Turmeric Root Powder, Ginger Root Powder, and others
  • Side Effects: No side effects.
  • Money-Back Guarantee: 6-month
  • Pricing: $49
  • What Makes Zenith Labs Joint N-11 Stand Out: This best joint supplement helps improve the long-term joint health of men and women by effectively reducing joint pain and swelling.

Supplement Description

Zenith Labs Joint N-11 is one of the top doctor-formulated joint supplements on the market that has a powerful natural formulation made with two ingredient blends, the absorption blend, and the rapid relief blend. It comes in the form of easily consumable capsules.

This advanced joint health formula has been tested to ensure its purity and potency. This joint pain supplement is regularly consumed by just taking two capsules.

A Zenith Labs Joint N-11 user, age 67, read,

“Before finding this solution, I had stiff hands, wrists, and fingers. I was not able to garden like I wanted to. After trying it, I no longer wake up with my hand in excruciating pain and numbness. My hands and wrists are less painful and have less stiffness. I’m able to do some gardening! Try this solution-it could help you too.”

This best joint supplement has been designed and formulated by a team of medical professionals and scientists of Zenith Labs, one of the known brands for nutritional and high-quality supplements. The researchers at Zenith Labs have made this natural supplement to support joint flexibility, repair cartilage decay, reduce inflammation, and alleviate joint pain.

ProJoint Plus


  • Key Ingredients: Glucosamine Sulfate, MSM, Boswellia Extract, and others
  • Side Effects: No adverse effects.
  • Money-Back Guarantee: NA
  • Pricing: $29.95
  • What Makes ProJoint Plus Stand Out: This powerful joint supplement helps men and women regain their healthy joints and bone health due to chondroitin sulfate and glucosamine sulfate.

Supplement Description

ProJoint Plus is better than most joint supplements as it contains chondroitin sulfate and glucosamine sulfate per serving.

It helps support your bone, knee, cartilage, and joint health. The formulation of this anti-inflammatory glucosamine supplement helps keep healthy joint movement, provides joint pain relief, reduces knee pain and muscle pain, and maintains overall joint health.

You are suggested to consume two to three of these capsules daily with food to experience proven benefits on your body.

A ProJoint Plus customer review reads,

“I’ve used ProJoint Plus for 1 month, taking 1 pill in the morning and 1 pill at night. After 2 weeks, I noticed the pain in my elbow begins to ease off. Now, I feel NO throbbing pain at all! I am buying a bottle for my husband to try!”

These glucosamine sulfate supplements and chondroitin supplements have been designed and formulated by the scientific board of Vita Balance Inc., one of the top brands of natural and high-quality supplements. The researchers at Vita Balance have made these anti-inflammatory capsules goodness-packed by adding chondroitin sulfate and glucosamine sulfate as the key ingredients.

1MD MoveMD


  • Key Ingredients: AprèsFlex Boswellia Serrata Extract, Zanthin Natural Astaxanthin, Type XIV Collagen, and others
  • Side Effects: No side effects.
  • Money-Back Guarantee: 90-day
  • Pricing: $43
  • What Makes 1MD MoveMD Stand Out: This one of the best joint supplements helps reduce inflammation in your joints which is a cause for chronic joint pain, unlike many joint supplements on the market.

Supplement Description

1MD MoveMD is a comprehensive joint supplement on the market that comes in capsules. It is known to support your joint, bone, and cartilage effectively with its formulation made using clinically-studied ingredients and a patented form of boswellic acid.

It is one such wheat-free, dairy-free, peanut-free, and shellfish-free supplement that helps reduce joint discomfort in as few as five days. These capsules help maintain connective tissue and reduce oxidative stress, thus effectively eliminating tissue stiffness and soreness.

A 1MD MoveMD user review reads,

“So I started 1MD 3 months ago boy, talk about a difference. I looked on google…Among other things and 1MD was at the top of the list. So I decided to try it. Well, it works. I still feel great, and I’m so happy I chose to try it. It works better than I thought it would.”

This fast-acting joint pain formula is manufactured by health professionals and nutrition experts at the brand 1MD Nutrition to support the overall joint health and well-being of individuals, irrespective of gender. It was designed in state-of-the-art registered and certified facilities keeping in mind the safety and health standards.

The 1MD MoveMD supplement has been recommended by 1MD Nutrition joint specialist named Dr. Adam Kreitenberg to reduce pain.

Nuzena Joint Support +


  • Key Ingredients: Chondroitin, bromelain, quercetin, and Boswellia serrata extract
  • Side Effects: No side effects.
  • Money-Back Guarantee: 30-day
  • Pricing: $45
  • What Makes Nuzena Joint Support + Stand Out: This joint pain relief supplement helps men and women experience proven joint and bone benefits.

Supplement Description

Nuzena Joint Support + is one of the best joint supplements on the market that contains pure and natural ingredients per serving, chondroitin sulfate and glucosamine sulfate. It helps provide support to your joint health and lowers your joint pain or arthritis pain significantly.

These glucosamine supplements are gluten-free, non-GMO, hormone-free, and sugar-free.

A Nuzena Joint Support + user review reads,

“This formula ticks all of the boxes for me. Firstly I was blown away at how much I noticed the improvements in my flexibility, but also a major decrease in joint stiffness in the morning which I had been struggling with (especially in the winter months). Secondly, the fact that all of the ingredients are natural is a big plus for me. I haven’t had any bad side effects at all, like I know many people get with some pain meds. I’ll be a lifetime user for sure.”

This supplement has been designed and formulated by the team at Nuzena. The people and their vision at Nuzena are all about providing a comprehensive and integrative approach to improving individuals’ overall health and well-being.

A team of health professionals at Nuzena has made the advanced formula for these joint anti-inflammatory supplements using high-quality and scientifically-backed ingredients to reduce pain.

Thrive Health Labs Joint Guard 360


  • What Makes Thrive Health Labs Joint Guard 360 Stand Out: This one of the best joint pain supplements on the market helps reduce the risks of rheumatoid arthritis symptoms, inflammation, and pain.

Supplement Description

Thrive Health Labs Joint Guard 360 is one of the top-rated joint supplements on the market that helps support bones, joints, and cartilage with the help of its formulation containing glucosamine hydrochloride and turmeric per serving.

This glucosamine hydrochloride supplement comes in the form of capsules, and it is also naturally free from additives and fillers. It has been manufactured in a state-of-the-art facility to reduce joint pain effects and support chronic pain management.

These researchers at Thrive Health Labs have made this glucosamine hydrochloride capsule power-packed and high-quality to reduce joint pain, knee pain, and arthritis pain after regular and recommended consumption.

Onnit Joint Oil


  • Key Ingredients: Fish Oil, Borage Oil, Avocado, and others
  • Side Effects: No adverse effects.
  • Money-Back Guarantee: 90-day
  • Pricing: $32.95
  • What Makes Onnit Joint Oil Stand Out: This joint supplement’s formulation helps improve joint function, thus helping treat joint pain and support the joint health of men and women.

Supplement Description

Onnit Joint Oil is among the best, with a powerful combination of goodness-packed ingredients, namely, omega-3 fatty acids and turmeric, to support the joint, bone, and cartilage health of men and women.

These additive-free and lab-tested fish oil supplements in liquid form have been manufactured in a state-of-the-art facility.

Regularly consuming these fish oil supplements in the recommended dosage helps provide significant pain relief, reduces inflammation in the connective tissues, and increases joint lubrication significantly.

This joint supplement in liquid form has been designed and formulated by a team of medical professionals and scientific minds. These learned researchers have made these fish oil supplements using omega-3 fatty acids.

UpWellness Golden Revive +


  • Key Ingredients: BCM-95 Curcumin, Boswellia, Magnesium, Quercetin, and others
  • Side Effects: No adverse effects.
  • Money-Back Guarantee: 60-day
  • Pricing: $60.30
  • What Makes UpWellness Golden Revive + Stand Out: This joint supplement stands out from the rest of the similar joint health supplements on the market due to its contribution to the joint health of men and women with its potent blend of natural ingredients.

Supplement Description

UpWellness Golden Revive + is among the best that provides joint and muscle support to men and women. This joint supplement uses a pure, safe, and effective combination of natural ingredients.

It is better than other joint supplements as it contains America’s most potent turmeric, BCM-95 curcumin which is 200 times stronger than raw turmeric. The absorption of these goodness-packed ingredients helps support healthy joints, relieve chronic joint pain, promote pain-free mobility, ease muscle tension, and improve blood circulation.

The advanced formula of UpWellness Golden Revive + is physician-formulated, 100% natural, vegan-friendly, and endorsed by professional athletes. A few of the professional athletes that recommend the consumption of this joint pain supplement include Charley Hull (LPGA tour winner and ladies European tour winner) and Brenden Steele (3 times PGA tour winner).

An UpWellness Golden Revive + user review mentioned on its official website reads,

“G R + saved me from pending knee replacement surgery & I tell Everyone I meet to save them from this trauma.. so far, I personally know of over thirty people that have listened and Loved this simple & extremely effective answer to ongoing, nagging pain! I was 86 when I started Golden Revive + with horrific knee pain… it took about two weeks of taking it faithfully until the pain was gone, and I canceled my surgery date. I have been taking it consistently ever since & totally pain-free & loving life, plus back to ice skating at almost 88!”

It is manufactured by UpWellness, a trusted brand for its natural supplements that support nutrient-rich living. The three founders of this brand are Jake Carney, Dr. Joshua Levitt, and Dr. Amanda Levitt.

A team of medical researchers and health professionals from UpWellness has designed the powerful formula for this joint pain supplement in registered and certified facilities.

Does Science Back The Ingredients In The Best Joint Supplements?

It’s no secret that natural ingredients have been used for centuries in traditional medicine to treat various ailments, including joint pain. However, with so many products claiming their effectiveness based on these natural ingredients, it’s essential to know whether science supports them.

Below we’ll look at some of the natural compounds found in the best joint supplements and evaluate whether scientific evidence supports their use.

By exploring recent research into joint health supplements, we hope to provide you with a better understanding of what works when relieving joint pain and improving overall mobility.

Vitamin D

Vitamin D has several roles in promoting healthy joints. One of its most essential functions is regulating calcium absorption and bone metabolism. Studies show that vitamin D deficiency can lead to diminished bone density and an increased risk of fractures.

Vitamin D plays a vital role in reducing inflammation in the body. Research suggests that vitamin D may help protect against certain autoimmune diseases by modulating immune system responses. Moreover, studies have shown that people with low vitamin D levels tend to have higher levels of inflammatory markers than those with adequate levels.

Also, some joint-specific studies suggest that maintaining adequate vitamin D levels may reduce cartilage loss and pain associated with osteoarthritis (OA). OA occurs when the cartilage covering bones wears down over time, ultimately causing friction between bones and significant joint pain.


Ashwagandha contains compounds called withanolides, which have been shown to decrease inflammation in joints. The herb also has analgesic properties that help alleviate pain associated with chronic conditions such as arthritis.

In addition to reducing inflammation and pain associated with joint conditions, Ashwagandha has shown promise in improving joint function.

A study published in the Journal of Ayurveda and Integrative Medicine found that subjects who took Ashwagandha supplements exhibited improved grip strength and knee extension compared to those who did not.


Omega-3 is a type of fatty acid essential for maintaining good health. It is found in fish, flaxseeds, and chia seeds. Omega-3 supports joint health and function by reducing inflammation in the body.

Inflammation is among the leading cause of joint pain and stiffness. Omega-3 helps reduce inflammation by blocking the production of certain enzymes responsible for causing inflammation. This can help reduce joint pain and swelling, making movement more manageable and comfortable.

Furthermore, omega-3 has been found to help protect against cartilage damage in the joints. Cartilage is the tissue that covers bones at the joint, providing cushion and smooth movement. Over time, cartilage can become damaged due to wear and tear or injury. Omega-3 helps to protect against this damage by reducing oxidative stress and promoting repair mechanisms within the body.

Hyaluronic Acid

Hyaluronic acid is a natural lubricant and cushion for joints, skin, eyes, and other connective tissues. It’s a sugar molecule that holds water and helps keep tissues well-lubricated and moist.

In the joints, synovial fluid surrounds the cartilage tissue. Hyaluronic acid and other substances like collagen and proteoglycans are present in this fluid. The synovial fluid helps decrease bone friction during movement while providing nutrients to cartilage cells that promote healing.

As we age or after an injury, our bodies may produce less of this fluid, leading to discomfort or loss of mobility in our joints. Supplementing with hyaluronic acid can replace depleted levels in the synovial fluid and provide additional cushioning support for the joints.

Andrographis Paniculata

Andrographis paniculata is an annual herb with green leaves and white-purple flowers. Its active components include diterpenoid lactones, flavonoids, xanthones, and other phytochemicals that exhibit various pharmacological activities.

Andrographolide, one of the main components in Andrographis paniculata, has been shown to have anti-inflammatory effects by inhibiting pro-inflammatory cytokines. Inflammation is critical in many joint disorders like osteoarthritis or rheumatoid arthritis, which can cause pain and discomfort.

Moreover, studies suggest that Andrographis paniculata may protect cartilage from breakdown by inhibiting matrix metalloproteinases (MMPs). Matrix metalloproteinases are enzymes responsible for breaking down cartilage tissue. Andrographis paniculata may help maintain healthy joints over time by preventing their activity.

Chondroitin Sulfate

Chondroitin sulfate works by providing structural support for joints while reducing inflammation by inhibiting enzymes that break down cartilage. Additionally, it may help prevent cartilage breakdown by acting as water-retaining molecules within the cartilage extracellular matrix. This increases shock absorption in our joints, decreasing their wear and tear.

Numerous studies have been conducted on chondroitin sulfate, showing excellent results. A randomized controlled trial published in The New England Journal of Medicine reported that after two years of treatment with chondroitin sulfate, participants experienced significant reductions in knee osteoarthritis symptoms compared to placebo tablets.

Glucosamine Sulfate

Glucosamine sulfate is a naturally occurring chemical in our bodies, particularly in joint cartilage. It is a building block for the molecules that make up joint cartilage and helps keep them strong and healthy. Unfortunately, as we age or experience injuries, the amount of glucosamine sulfate present in our bodies decreases, which can result in joint damage and pain.

One study published in the US National Library of Medicine assessed the effects of glucosamine on osteoarthritis patients over 24 weeks. The results showed significant improvement in knee pain reduction for those treated with glucosamine compared to placebo.

Boswellic Acid

Boswellic acid is an active ingredient found in the resin of Boswellia serrata trees – also known as Frankincense trees – which grow in India, Africa, and other parts of Asia. The resin has been used for centuries to treat various conditions such as arthritis, asthma, and digestive disorders.

Boswellic acid works by inhibiting 5-lipoxygenase (5-LOX), an enzyme that produces leukotrienes. Leukotrienes contribute to inflammation within the joints leading to increased pain and stiffness.

In a randomized controlled trial published in Phytotherapy Research, participants were given 100 or 250 mg of boswellic acid supplements daily or a placebo for eight weeks. Those who took Boswellia supplements experienced a significant reduction in knee pain compared with those taking placebos.

Alpha Lipoic Acid

Several studies suggest that ALA may have a positive effect on joint health. One of the ways it achieves this is by acting as an antioxidant, protecting against free radical damage, which can cause inflammation and damage to joints over time.

In one study published in Rheumatology International, 51 patients with osteoarthritis were given either 600 mg of ALA or a placebo daily for 12 weeks. The group taking ALA experienced significant improvements in mobility and an overall reduction in pain compared to the placebo group.

Factors Considered Before Curating The Best Joint Supplements

The key factors considered before curating this list of different brands’ top 10 joint supplements are mentioned below:


One of the top-ranking factors our team considers is the ingredients used in making joint supplements. In this list, we have only considered those supplements for joint pain relief whose formulations contain entirely natural ingredients, namely fish oil, vitamin D, omega-3 fatty acids, turmeric, etc., and whose work is based on their goodness and quality.

Brand Transparency and Advertised Health Benefits

Choosing joint supplements from a company with an honest and transparent marketing approach is essential from a customer perspective. We make sure to choose those supplements for this list so that the customers do not feel scammed after purchasing the joint health supplements and experiencing fake results.

Money-Back Guarantee

A supplement company that offers a money-back deal makes the consumers feel that their purchase is risk-free and they can try the supplement for themselves. They think that due to a secure money-back guarantee, they could return the product to the company and get their invested money back upon dissatisfaction.

The Top 10 Best Joint Supplements Of 2023 Conclusion

To conclude this review, we can say that joint pain supplements are becoming prevalent these days to maintain the overall joint health of men and women. These supplements help treat arthritis pain and other joint issues.

So, to find the joint pain relief supplement best for your health, check out the supplements mentioned above.

Also Read: Best Turmeric Supplements 2023: Top Turmeric Products

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The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team. Please know we only recommend high-quality products.


Please understand that any advice or guidelines revealed here are not even remotely substitutes for sound medical or financial advice from a licensed healthcare provider or certified financial advisor. Make sure to consult with a professional physician or financial consultant before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary and are not guaranteed as the statements regarding these products have not been evaluated by the Food and Drug Administration or Health Canada. The efficacy of these products has not been confirmed by FDA, or Health Canada approved research. These products are not intended to diagnose, treat, cure or prevent any disease and do not provide any kind of get-rich money scheme. Reviewer is not responsible for pricing inaccuracies. Check product sales page for final prices.

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